Wolfram Syndrome

Also known as


A progressive neurodegenerative condition causing Diabetes Insipidus(water diabetes), Diabetes Mellitus, Optic Atrophy(loss of vision), Deafness. Can also cause choking, neurogenic bladder, anxiety, depression, colour blindness, loss of 3D vision and neurological issues

Condition details

Juvenile onset type 1 diabetes followed by optic atrophy, which can vary from reduced vision to complete loss of sight, & colour blindness. Not everyone develops all the different parts of the condition and everyone varies in degrees of how they are affected.

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Photos of affected individuals

Click images to enlarge.

  • No baby imageBaby
  • No toddler imageToddler
  • No child 4-10 imageChild 4-10
  • No child 10-18 imageChild 10-18
  • No adult imageAdult

Typical age range of first manifestation

  • Does not manifest in Baby
  • Does not manifest in Toddler
  • Can manifest in Child 4-10
  • Does not manifest in Child 10-18
  • Does not manifest in Adult


Child 4-10
Lay terms Clinical terms
  • Type 1 Diabetes Loss of vision
  • Diabetes Mellitus Optic Atrophy
Child 10-18
Lay terms Clinical terms
  • Water Diabetes/ Dysfunctional Bladder Reduced/loss of hearing
  • Diabetes Insipidus Deafness
Lay terms Clinical terms
  • Anxiety Depression

Affected genes identified to date

  • WSF1

Inheritance patterns

Is Autosomal recessive

Are carriers affected?

can have mild symptoms of parts of the condition

How many are affected?


Support groups and organisations

Mrs Tracy Lynch
Wolfram Syndrome UK
9 Church Way
West Sussex
BN13 1HD
Tel 01903 211358
Ms Rachel Bates
16 Royal Crescent
GL50 3DA
Tel 0845 458 8171

Known experts

Prof Timothy Barrett
Field of interestWolfram Syndrome, Alstrom Syndrome, Bardet Biedel
Birmingham Children's Hospital
Steelhouse Lane
B4 6NH
Tel 0121 3339272
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