Wolfram Syndrome

Also known as

  • DIDMOAD

A progressive neurodegenerative condition causing Diabetes Insipidus(water diabetes), Diabetes Mellitus, Optic Atrophy(loss of vision), Deafness. Can also cause choking, neurogenic bladder, anxiety, depression, colour blindness, loss of 3D vision and neurological issues

Condition details

Juvenile onset type 1 diabetes followed by optic atrophy, which can vary from reduced vision to complete loss of sight, & colour blindness. Not everyone develops all the different parts of the condition and everyone varies in degrees of how they are affected.

I would like to edit or add detail to this database entry

Photos of affected individuals

Click images to enlarge.

  • No baby imageBaby
  • No toddler imageToddler
  • No child 4-10 imageChild 4-10
  • No child 10-18 imageChild 10-18
  • No adult imageAdult

Typical age range of first manifestation

  • Does not manifest in Baby
  • Does not manifest in Toddler
  • Can manifest in Child 4-10
  • Does not manifest in Child 10-18
  • Does not manifest in Adult

Symptoms

Child 4-10
Lay terms Clinical terms
  • Type 1 Diabetes Loss of vision
  • Diabetes Mellitus Optic Atrophy
Child 10-18
Lay terms Clinical terms
  • Water Diabetes/ Dysfunctional Bladder Reduced/loss of hearing
  • Diabetes Insipidus Deafness
Adult
Lay terms Clinical terms
  • Anxiety Depression

Affected genes identified to date

  • WSF1

Inheritance patterns

Is Autosomal recessive

Are carriers affected?

can have mild symptoms of parts of the condition

How many are affected?

1:750,000

Support groups and organisations

Mrs Tracy Lynch
Wolfram Syndrome UK
9 Church Way
Worthing
West Sussex
BN13 1HD
England
Tel 01903 211358
Facebook
Ms Rachel Bates
WellChild
16 Royal Crescent
Cheltenham
Gloucestershire
GL50 3DA
England
Tel 0845 458 8171
Facebook

Known experts

Prof Timothy Barrett
Field of interestWolfram Syndrome, Alstrom Syndrome, Bardet Biedel
Birmingham Children's Hospital
Steelhouse Lane
Birmingham
B4 6NH
England
Tel 0121 3339272
Facebook
I would like to edit or add detail to this database entry

Please let us know more about you

In order to allow you to edit this form, please fill in the fields below and click submit to proceed to to the editing page.

used only if we have questions about your entry.

Share this page

Welcome to the GDUK network

If this is the first time you have searched for information on a particular condition, details you find here may be distressing.

» If you would rather read our Newly Diagnosed section for parents and carers first click here