Also known as

  • A neuronal migration disorder

A disorder of the structure of the brain resulting from a genetic malfunction in which the protein, Tubulin, is not released at the correct time in a developing brain. As a result in very early stages of brain development, complex malformations occur as cells are sent to the wrong place.

Condition details

It is characterised by very complicated and numerous brain malformations. Each person may have different misshaped or malformed parts to their brain and so the effects and the extent of their disabilities will vary.

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Photos of affected individuals

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  • No baby imageBaby
  • No toddler imageToddler
  • No child 4-10 imageChild 4-10
  • No child 10-18 imageChild 10-18
  • No adult imageAdult

Typical age range of first manifestation

  • Can manifest in Baby
  • Does not manifest in Toddler
  • Does not manifest in Child 4-10
  • Does not manifest in Child 10-18
  • Does not manifest in Adult


Lay terms Clinical terms
  • Flat or very wiggly brain scan Missing parts of brain
  • polymicrogyria and lissencephaly Agenesis

Affected genes identified to date

  • TUBB2B
  • TUBA1A

Inheritance patterns

Are carriers affected?

How many are affected?

Very few

Support groups and organisations

No groups found

Known experts

No experts found

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