Loeys-Dietz Syndrome

Also known as

  • LDS

Loeys–Dietz syndrome (LDS) is an autosomal dominant genetic connective tissue disorder. The disorder is marked by aneurysms in the aorta, often in children. The aorta may also undergo sudden dissection in the weakened layers of the wall of aorta.

Condition details

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Photos of affected individuals

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  • No baby imageBaby
  • No toddler imageToddler
  • No child 4-10 imageChild 4-10
  • No child 10-18 imageChild 10-18
  • No adult imageAdult

Typical age range of first manifestation

  • Does not manifest in Baby
  • Does not manifest in Toddler
  • Does not manifest in Child 4-10
  • Does not manifest in Child 10-18
  • Does not manifest in Adult


Affected genes identified to date

  • 1A TGFBR1 Also known as Furlong disease 1B TGFBR2 2A TGFBR1 2B TGFBR2 Previously known as Marfan syndrome type 2 3 SMAD3 Also known as Aneurysms-osteoarthritis syndrome

Inheritance patterns

Are carriers affected?

How many are affected?

Support groups and organisations

The Marfan Forum

Known experts

No experts found

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