Hypophosphatasia

Also known as

  • HPP (soft bones)

Defective gene which affects bone mineralisation. There are different levels of physical presentation depending on what age symptoms emerge. Children can be severely affected, sometimes it is a fatal disease or results in severe deformities. I have a mild adult onset form which is characterised by stress fractures in feet, poor dentition and osteo arthritis.

Condition details

I would like to edit or add detail to this database entry

Photos of affected individuals

Click images to enlarge.

  • No baby imageBaby
  • No toddler imageToddler
  • No child 4-10 imageChild 4-10
  • No child 10-18 imageChild 10-18
  • No adult imageAdult

Typical age range of first manifestation

  • Does not manifest in Baby
  • Does not manifest in Toddler
  • Does not manifest in Child 4-10
  • Does not manifest in Child 10-18
  • Can manifest in Adult

Symptoms

Affected genes identified to date

Inheritance patterns

Is Autosomal dominant

Are carriers affected?

Yes

How many are affected?

Support groups and organisations

No groups found

Known experts

No experts found

I would like to edit or add detail to this database entry

Please let us know more about you

In order to allow you to edit this form, please fill in the fields below and click submit to proceed to to the editing page.

used only if we have questions about your entry.

Share this page

Welcome to the GDUK network

If this is the first time you have searched for information on a particular condition, details you find here may be distressing.

» If you would rather read our Newly Diagnosed section for parents and carers first click here